Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Authors
Kathryn F. Mills, Shohei Yoshida,
Liana R. Stein, …, Koji Uchida,
Jun Yoshino, Shin-ichiro Imai

Correspondence
jyoshino@wustl.edu (J.Y.),
imaishin@wustl.edu (S.I.)

Mills et al. conducted a 12-month-long administration of nicotinamide mononucleotide (NMN), a key natural NAD+ intermediate, to normal wild-type mice, demonstrating that NMN effectively mitigates age-associated physiological decline in mice without any obvious toxicity. These results highlight the significant potential of NMN as an effective anti-aging intervention in humans.